Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth.

ABSTRACT: Increases in impulsivity and negative affect (e.g., neuroticism) are common during adolescence and are both associated with risk for alcohol-use initiation and other risk behaviors. Whole-brain functional connectivity approaches-when coupled with appropriate cross-validation-enable identification of complex neural networks subserving individual differences in dimensional traits (hereafter referred to as 'neural signatures'). Here, we analyzed functional connectivity data acquired at age 19 from individuals enrolled in a multisite European study of adolescent development (N ~ 1100) using connectome-based predictive modeling. Network anatomies of these dimensional phenotypes were compared with one another and with a previously identified alcohol-use risk network to identify shared and unique

SUBMITTER: Cheng A 

PROVIDER: S-EPMC12815650 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature