A single glucocorticoid response element regulates sociability in a sex-specific manner.

ABSTRACT: Glucocorticoid receptors (GRs) regulate transcription to reduce inflammatory processes, modulate neuron function, and influence behavior. However, the precise loci bound by GRs that are critically important for these effects have not been fully determined. Here, we deleted the GR binding site near the sphingosine-1-phosphate receptor 3 (S1PR3) gene using a CRISPR/Cas9 approach in rats (S1PR3^GRE-/GRE- rats). Socially defeated S1PR3^GRE-/GRE- males displayed increased inflammatory markers and reduced sociability compared to defeated wild-type (WT) controls. Similar effects were observed in non-stressed females, indicating a greater dependence on the regulation of S1PR3 by GRs in females. Coherent neural activity between the locus coeruleus (LC) and medial prefrontal cort

SUBMITTER: Corbett BF 

PROVIDER: S-EPMC12815654 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature