Polygenic scores for psychiatric traits mediate the impact of multigenerational history for depression on offspring psychopathology.

ABSTRACT: A family history of depression is a well-documented risk factor for offspring psychopathology. However, the genetic mechanisms underlying the intergenerational transmission of depression remain unclear. We used genetic, family history, and diagnostic data from 11,875 9-10 year-old children from the Adolescent Brain Cognitive Development study. We estimated and investigated the children's polygenic scores (PGSs) for 30 distinct traits and their association with a family history of depression (including grandparents and parents) and the children's overall psychopathology through logistic regression analyses. We assessed the role of polygenic risk for psychiatric disorders in mediating the transmission of depression from one generation to the next. Among 11,875 multi-ancestry children, 8111 p

SUBMITTER: Lee E 

PROVIDER: S-EPMC12815659 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature