Molecular and topographic mapping of antipsychotic effects: a meta-analysis of postsynaptic density proteins in animal models with translational implications.

ABSTRACT:

Background

While antipsychotics primarily target dopamine D₂ receptor, the putative synaptic mechanisms underlying their therapeutic effects remain unclear. Postsynaptic density (PSD) at glutamatergic synapses represents a dynamic protein network involved in synaptic plasticity and neurotransmission, whose dysfunction has been implicated in the pathophysiology of schizophrenia and bipolar disorder. This study aims to explore, for the first time, with a quantitative meta-analytical approach, how antipsychotic treatments affect PSD molecules across various brain regions in preclinical settings, which may overcome the heterogeneity of human studies.

Methods

We systematically reviewed and meta-analyzed peer-reviewed preclinical studies reporting quantitative effects o

SUBMITTER: De Simone G 

PROVIDER: S-EPMC12815681 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature