Associations between trajectories of plasma biomarkers for Alzheimer's disease, brain structures, and cognitive function: a prospective cohort study in the UK Biobank.

ABSTRACT: Plasma amyloid-β(Aβ)42/40 ratio, glial fibrillary acidic protein (GFAP), neurofilament light (NfL), and phosphorylated tau181(p-tau181) are promising biomarkers for Alzheimer's disease (AD)-related pathology. We aimed to explore the longitudinal trajectories of these biomarkers in association with changes in structural brain markers and cognition, and the impact of cognitive reserve on their associations with cognitive function. This cohort study included 1270 individuals (mean age 59.7 years; 58.9% women) derived from the UK Biobank who had data on plasma biomarkers available at baseline (2014-2020); of these, data were available in 904 individuals for brain MRI scans and in 1183 for cognitive function. In 2021-2022, follow-up brain MRI markers and cognitive function were assessed. Plasma

SUBMITTER: Huang X 

PROVIDER: S-EPMC12815683 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature