HiPSC-derived cortical neurons from ADHD individuals reveal dysregulated glutamatergic development.

ABSTRACT: Attention-deficit/hyperactivity disorder (ADHD) is a chronic neurodevelopmental disorder characterised by inattention, hyperactivity, and impulsivity, significantly impacting life quality and mortality. It is among the most heritable neuropsychiatric disorders, yet its aetiology remains unclear, hindering the development of novel medications. Previously, research has primarily focused on the dopaminergic and noradrenergic systems using animal models. However, there is growing evidence for a role of the glutamatergic system in ADHD pathomechanisms, and a translational failure between pre-clinical animal models and human clinical trials. We therefore established and characterised a functional cortical neuronal model using human induced pluripotent stem cells (hiPSCs) to investigate glutamate

SUBMITTER: McNeill RV 

PROVIDER: S-EPMC12815685 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature