GABA_A receptor availability in clinical high-risk and first-episode psychosis: a [¹¹C]Ro15-4513 positron emission tomography study.

ABSTRACT: Disrupted gamma-aminobutyric acid (GABA) neurotransmission may contribute to the pathophysiology of schizophrenia. Reductions in hippocampal GABAergic neurons have been found in schizophrenia, and increased hippocampal perfusion has been described in schizophrenia and in people at clinical high-risk for psychosis (CHRp). We have also found decreases in hippocampal GABA_A receptors containing the α5 subunit (GABA_ARα5) in a well-validated neurodevelopmental rat model of relevance for schizophrenia. Positive allosteric modulation of these receptors in the hippocampus using a specific compound was shown to reverse the behavioural and neurophysiological phenotypes of this model. However, whether GABA_ARα5 availability is dysregulated in the psychosis spectrum at t

SUBMITTER: Lukow PB 

PROVIDER: S-EPMC12815687 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature