<i>Latilactobacillus curvatus</i> DCF0620 and postbiotics derived from soybean germ reduce colitis severity by modulating fibrosis and gut dysbiosis.

ABSTRACT:

Background

Given that microbiota dysbiosis is closely linked to the initiation and progression of inflammatory bowel disease (IBD), extensive research is underway to utilize beneficial probiotics as a therapeutic strategy for IBD. In this study, we compared the therapeutic efficacy of Lacticaseibacillus paracasei (L. paracasei) DCF0420, Lactiplantibacillus plantarum (L. plantarum) DCF0514, and Latilactobacillus curvatus (L. curvatus) DCF0620 and also investigated the potential of soybean germ-based postbiotics from DCF0620 as a treatment for IBD.

Methods

Live L. paracasei DCF0420, L. plantarum DCF0514, L. curvatus DCF0620, or postbiotics were orally administered to DSS-induced colitis mice starting 7 days before

SUBMITTER: Park JS 

PROVIDER: S-EPMC12815751 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature