Olanzapine affects bone formation via oral <i>Enterococcus</i> through <i>SAA1</i> gene and extracellular matrix-related pathways.

ABSTRACT:

Background

Olanzapine is a commonly used drug in the treatment of schizophrenia, but the mechanism of abnormal bone metabolism caused by olanzapine is still unclear. The change of microflora may be an important factor leading to the change of bone metabolism. Therefore, the purpose of this study was to explore a plausible hypothesis that olanzapine may aggravate abnormal bone metabolism and cause bacterial imbalance in patients with schizophrenia.

Methods

This study intervened in mice by gavage with olanzapine to detect changes in alveolar bone tissue and oral microbiota. The effect of related bacteria on osteogenesis was further examined.

Results

The results showed that Enterococcus increased, the bone mass and type I collagen of alveolar bone decreased. En

SUBMITTER: Yuan H 

PROVIDER: S-EPMC12815755 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature