Comparative effectiveness of bone-protective interventions for aromatase inhibitors-induced bone loss in postmenopausal women with early breast cancer: a network meta-analysis.

ABSTRACT:

Objectives

This network meta-analysis (NMA) aims to compare the efficacy of bone-protective interventions in preventing AIs-induced bone loss at lumbar spine and hip sites.

Methods

We systematically searched PubMed, Embase, Cochrane Library, Web of Science, and clinical trial registries from inception to February 28, 2025, to identify randomized controlled trials (RCTs) evaluating bone-protective interventions in postmenopausal women with breast cancer receiving AI therapy. Primary outcomes were changes in bone mineral density (BMD) at lumbar spine and total hip at 12 and 24 months. Network meta-analysis was performed using Bayesian methods with R software and WinBUGS. Treatment rankings were assessed using surface under the cumulative ranking curve (SUCRA) values.

Result

SUBMITTER: Xu Y 

PROVIDER: S-EPMC12815783 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature