Metabolic consequences of perinatal bisphenol A and 17α-Ethinylestradiol exposure manifest in circadian alterations of energy homeostasis in adult male mice.

ABSTRACT:

Introduction

Environmental estrogenic chemicals can cross the maternal-fetal barrier and disrupt endocrine and metabolic regulation in the developing embryo/fetus. Bisphenol A (BPA) and 17α-ethinylestradiol (EE2) are widely present in the environment and have been linked to increased cardio-metabolic disease risk.

Purpose

This study investigated the effects of maternal BPA and EE2 exposure on metabolic function and circadian energy regulation in male offspring.

Methods

Pregnant and lactating dams were chronically administered BPA (20 µg/kg bw/day) or EE2 (0.01 µg/kg bw/day) via osmotic minipumps from gestational day 9 to postnatal day 21 to mimic environmental exposure. Adult male offspring (60-80 days old) were assessed for body composition, fasting glucose, and meta

SUBMITTER: Kallo I 

PROVIDER: S-EPMC12815843 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature