Very early tilt-table verticalization unmasks impaired cerebral autoregulation within 24 h after endovascular thrombectomy: a transcranial Doppler study.

ABSTRACT:

Introduction

Impaired cerebral autoregulation in the acute phase after ischemic stroke may compromise cerebral perfusion during very early mobilization, posing a risk for secondary injury.

Methods

This observational cross-sectional study investigated the mechanistic response of cerebral and systemic hemodynamics during progressive tilt-table verticalization in 25 patients within 24 h post-thrombectomy and 31 healthy age-matched controls. Middle cerebral artery blood flow velocity (CBFV) was continuously recorded via transcranial Doppler across six full-body tilt positions (-5° to 70°), alongside blood pressure, heart rate, and oxygen saturation.

Results

CBFV declined progressively with increasing tilt in both groups (p < 0.001), but the reduction at 70° was sig

SUBMITTER: Deseoe J 

PROVIDER: S-EPMC12815858 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature