EEG changes associated with hallucinations caused by Charles Bonnet Syndrome.

ABSTRACT: Charles Bonnet syndrome (CBS) is characterised by the presence of visual hallucinations following visual loss in many patients. The neuropathophysiology of CBS is poorly understood. We used electroencephalography (EEG) in individuals with frequent hallucinations in order to identify changes in neural activity that co-occur with hallucination onset. We found reduced α power in occipital electrodes at the onset of the hallucinations compared to offset (p < 0.05), suggesting that intermittent periods of low endogenous alpha may create the neural conditions for hallucination to emerge in CBS patients. This is the first group study that shows a repeatable marker of brain activity changes in CBS that occur either at the onset or just prior to the onset of the hallucination. This offers im

SUBMITTER: Jolly JK 

PROVIDER: S-EPMC12815872 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature