Antihypertensive Past Adherence Trajectories and Risk of Cardiotoxicity Among Adults Initiating Anthracycline Treatment.

ABSTRACT:

Background

Poor blood pressure control and low adherence to antihypertensives increase the risk for anthracycline-induced cardiotoxicity (AIC) in hypertensive cancer patients. Little is known about whether past adherence to antihypertensive medications can reduce the risk of AIC in patients initiating anthracyclines. We examined adherence to antihypertensives pre-anthracycline initiation and its association with the risk of AIC.

Methods

We conducted a retrospective cohort study using a 25% random sample of IQVIA PharMetrics Plus for Academics US health plan claims, 2006-2022. We identified individuals 18- 64 years old, with hypertension, diagnosed with breast cancer or lymphoma (Hodgkin's or Non-Hodgkin's) 9 months before the anthracycline treatment initiation (index date).

SUBMITTER: Damachi U 

PROVIDER: S-EPMC12815894 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature