Exploring the pangenome of Mycoplasma hyorhinis in search of potential virulence markers.

ABSTRACT: Mycoplasma hyorhinis (homotypic synonym of Mesomycoplasma hyorhinis) is a pathobiont from the upper respiratory tract of pigs. Under unclear circumstances, it can disseminate systemically and cause disease. Although some studies have reported different infectious capabilities among strains, no factors have been directly linked to virulence. This study aimed to analyze the core and accessory genes of all available M. hyorhinis strains (pangenome) to identify potential virulence markers. We characterized the pangenome of 110 strains, including isolates from healthy (nasal cavity) and diseased (systemic organs, nasal cavity or lung) animals. Comparative analyses were performed according to the clinical background. Although most putative virulence genes were shared, we identified several genes

SUBMITTER: Obregon-Gutierrez P 

PROVIDER: S-EPMC12815946 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature