Perioperative ketorolac use and postoperative acute kidney injury in elderly patients undergoing noncardiac surgery: a retrospective cohort study.

ABSTRACT: The use of nonsteroidal anti-inflammatory drugs, particularly ketorolac, in elderly patients is not recommended due to concerns about acute kidney injury (AKI). However, the effect of perioperative ketorolac use on postoperative AKI in elderly patients remains uncertain. We retrospectively reviewed patients aged ≥ 60 years who underwent noncardiac surgery lasting ≥ 1 h and were hospitalized for more than 2 days after surgery between January 2011 and June 2019. The ketorolac group included patients who received intravenous ketorolac in the operating room or post-anesthesia care unit. The primary outcome was postoperative AKI, defined according to the Kidney Disease: Improving Global Outcomes criteria. Propensity score matching (PSM) at a 1:3 ratio was performed to adjust for confounders, an

SUBMITTER: Oh AR 

PROVIDER: S-EPMC12815955 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature