Genetic insights and mechanistic parallels in gestational diabetes mellitus and type 2 diabetes.

ABSTRACT: Gestational diabetes mellitus (GDM) has a high heritability and frequently co-occurs with type 2 diabetes (T2D), indicating shared genetic mechanisms. Firstly, we employed RHOGE to ascertain the genetic correlation and putative causal directions between GDM and T2D. Subsequently, the Genotype-Tissue Expression Project v8 eQTls files and the FinnGen R11 dataset were employed to conduct cross-tissue transcriptome association studies, Functional Summary-based Imputation in single tissues, and Gene Analysis combined with Multimarker Analysis of Genomic Annotation for GDM and T2D, respectively. A total of 5 genes were identified as GDM susceptibility and 97 genes linked to T2D susceptibility. Of these, four genes (COBLL1, NRBP1, IFT172 and TRIM54) were identified as being shared. Mendelian rand

SUBMITTER: Fu L 

PROVIDER: S-EPMC12816006 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature