Prescribed drugs and comorbidities as risk factors for Torsades de Pointes arrhythmia: a Swedish population-based cohort study.

ABSTRACT:

Purpose

Drug-induced long QT interval syndrome (LQTS) is a risk for Torsade de Pointes (TdP) arrhythmia. The purpose was to investigate patients diagnosed with TdP in relation to dispensed risk drugs, the presence of comorbidities, and sex-differences.

Methods

All patients with a first episode of a registered TdP diagnosis in the National Patient Register between 2006 and 2018 were included in this register-based cohort study. Comorbidities within five years and medications dispensed within 90 days prior to TdP diagnosis were retrieved. Drugs were classified for their risk to cause TdP ("risk drugs") using two different Clinical Decision Support Systems (CredibleMeds and Janusmed).

Results

The cohort consisted of 762 patients (50% females) with TdP, median age 72 year

SUBMITTER: Andersson ML 

PROVIDER: S-EPMC12816018 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature