Elevated IGF1R and abnormal methylated IGF1R in immune thrombocytopenia.

ABSTRACT: To investigate possible role of IGF1R/PI3K/Akt/mTOR signal pathway related genes in the pathogenesis of ITP. Akt/mTOR Total Protein 11-plex Magnetic Bead Kit was used for measurement of related genes of IGF1R/PI3K/Akt/mTOR signal pathway in ITP patients and healthy controls. Genome-wide patterns of DNA methylation and gene expression with IGF1R/PI3K/Akt/mTOR signal pathway were determined in ITP and controls respectively. Elevated protein levels of IGF1R was found in ITP patients compared to healthy controls [Median Fluorescence Intensity (inter-quartile range, IQR), 2551.0 (941.1-4213.0) vs 786.50(276.0-2555.0), P<0.05], the level of p70S6K in ITP patients with active disease was significantly higher [801.0(609.5-1012.0)] than that in healthy controls [652.3(531.8-776.6), P<0.05]. Further

SUBMITTER: Zhu X 

PROVIDER: S-EPMC12816080 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature