Low PAPP-A levels and their association with adverse perinatal outcomes in twin pregnancies.

ABSTRACT:

Purpose

While in singleton pregnancies the maternal serum biomarkers used in the first-trimester screening for aneuploidies, particularly PAPP-A, may be, also, used as predictors of adverse perinatal outcomes, there is a scarcity of data regarding the association of first-trimester biomarkers with unfavorable pregnancy outcomes in twin pregnancies. The main purpose of our study was to evaluate the association of low PAPP-A levels in twin pregnancies with the subsequent development of perinatal complications.

Methods

454 twin pregnancies were recruited over a period of 11 years, and their data were analyzed retrospectively. First trimester assessment at 11 + 0-13 + 6 weeks included examination of fetal anatomy and markers of aneuploidy and measurement of the maternal serum co

SUBMITTER: Ioakeim S 

PROVIDER: S-EPMC12816117 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature