NSUN5 as a Prognostic Biomarker Correlates with Malignant Phenotype and Therapeutic Target in Glioma.

ABSTRACT:

Background

NSUN5 is a conserved RNA methyltransferase whose oncogenic role has been demonstrated in various cancers. However, its function and prognostic value in gliomas remain unclear.

Methods

In this study, we systematically analyzed the expression and functional associations of NSUN5 in glioma using data from The Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA) databases. A total of 117 machine learning algorithm combinations were employed to construct and validate a prognostic model for glioma patients. In addition, in vitro experiments were performed to further validate the expression and biological functions of NSUN5.

Results

NSUN5 expression is significantly upregulated in glioma and is positively associated with tumor malignancy and poor

SUBMITTER: Wenhao Y 

PROVIDER: S-EPMC12816160 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature