Yeast protein modulates metabolites derived from the human gut microbiota of older male adults <i>ex vivo</i> to strengthen gut barrier function and reduce inflammation.

ABSTRACT:

Introduction

The rising global demand for protein is accelerating interest in sustainable alternatives with health benefits. While glycans are well-known for supporting gut health, the role of dietary proteins in promoting healthy aging via microbiome modulation is less understood. Yeast protein (YP) represents a sustainable, non-animal, hypoallergenic option.

Methods

Using the clinically predictive ex vivo SIFR^® technology (Systemic Intestinal Fermentation Research), we examined how YP influences the microbiome of older human adults (50-65 years, n = 6), comparing its effects to whey protein isolate (WPI) and soy protein isolate (SPI).

Results

At a dose equivalent to 40 g/day, all protein sources supported gut barrier integrity and reduced in

SUBMITTER: Van den Abbeele P 

PROVIDER: S-EPMC12816187 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature