A diagnostic prediction model was established based on the clinical characteristics of multicenter children with Kawasaki disease in Xinjiang.

ABSTRACT:

Introduction

Kawasaki disease (KD) is a serious pediatric systemic vasculitis that may cause cardiovascular complications, including coronary artery lesions (CAL). This study aimed to evaluate the predictive value of peripheral blood lymphocyte subsets for intravenous immunoglobulin (IVIG) treatment sensitivity in children with KD in Xinjiang.

Methods

This multicenter retrospective study collected clinical and laboratory data from 142 children with KD and 120 controls with infectious fever across several hospitals in Xinjiang from June 2022 to December 2024. Peripheral blood lymphocyte subsets and immunoglobulins were analyzed. Multivariate logistic regression was used to identify risk factors for IVIG non-responsiveness, and ROC curve analyses were performed to evaluate dia

SUBMITTER: Niu M 

PROVIDER: S-EPMC12816189 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature