Multi-omics study of the anti-colorectal cancer mechanisms of formononetin in <i>Hedysari Radix</i>.

ABSTRACT:

Background

Hedysari Radix (HR), commonly known as Hong-Qi in Chinese, is a traditional Chinese herbal medicine recognized for possessing anti-inflammatory and anti-tumor properties. While the polysaccharides in HR have been extensively studied, other HR metabolites and their potential anti-tumor properties remain largely unknown.

Methods

We employed a multi-omics strategy integrating metabolomics, network analysis, proteomics, phosphoproteomics, and molecular docking to identify HR metabolites with anti-colorectal cancer (CRC) property and investigate underlying mechanisms.

Results

Using mass spectrometry-based metabolomics, we identified 1,292 metabolites across eight processed HR products. Key metabolites including medicarpin, formononetin, naringenin,

SUBMITTER: Rao J 

PROVIDER: S-EPMC12816190 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature