β-sitosterol ameliorates myocardial infarction injury via modulating the NF-κB and necroptosis signaling pathways.

ABSTRACT:

Introduction

Acute myocardial infarction (MI) is a leading global cause of morbidity and mortality, where inflammatory response and programmed cell death (PCD) are critical in disease progression. β-sitosterol (β-SITO), a phytosterol with known cardioprotective effects, has been implicated in cardiovascular diseases, but its specific role and mechanisms in MI remain underexplored.

Methods

This study employed both in vivo and in vitro models. Male C57BL/6J mice with MI were used to evaluate the effects of β-SITO treatment. Cardiac function was assessed via echocardiography, infarct size and fibrosis were analyzed histologically. In vitro, cardiomyocyte viability under hypoxia and TGF-β-induced cardiac fibroblast activation were examined. Mechanistic insig

SUBMITTER: Xu JJ 

PROVIDER: S-EPMC12816229 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature