Assessment of proteomic salivary biomarkers for diagnosis of early childhood caries: a systematic review.

ABSTRACT:

Background

Severe early childhood caries (s-ECC) remains a highly prevalent condition among children worldwide, posing a considerable burden in both developed and developing regions. This systematic review seeks to comprehensively identify, synthesize, and critically evaluate available evidence on salivary proteomic and peptidomic biomarkers that may aid in the diagnosis or risk assessment of ECC.

Aim and objectives

This study aims to evaluate any difference in the level of proteomic salivary biomarkers in children with and without ECC.

Methods

A comprehensive search was conducted across four major electronic databases: the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE via PubMed, Scopus, and Google Scholar. From an initial yield of 1,253 records,

SUBMITTER: Shivaprakash PK 

PROVIDER: S-EPMC12816231 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature