Towards a map of the immune system manipulation network by <i>Trypanosoma cruzi</i>.

ABSTRACT: Trypanosoma cruzi (T. cruzi), the protozoan parasite that causes Chagas disease, remains a major public health challenge, with more than six million people infected worldwide. Despite more than a century of research and extensive evaluation of different strategies, no vaccine has progressed to late-phase clinical trials. This failure highlights the need to better understand host-parasite interactions, with special emphasis on the immunoregulatory pathways exploited by the parasite. In this review, we propose an initial comprehensive map of the T. cruzi immune manipulation network, integrating research on numerous parasite and host components involved. Five main cores of manipulation are proposed, including how T. cruzi skews macrophage polarization toward regula

SUBMITTER: Gamba JC 

PROVIDER: S-EPMC12816262 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature