Association of estimated liver fibrosis with carotid but not femoral atherosclerotic burden: the ILERVAS cohort.

ABSTRACT:

Introduction

Advanced liver fibrosis, a key complication of metabolic dysfunction-associated steatotic liver disease, has been increasingly linked to extrahepatic conditions, including type 2 diabetes, obesity, and cardiovascular disease. However, the specific association of liver fibrosis in the development and progression of subclinical atheromatous disease across vascular territories remains poorly understood. This study evaluates the utility of two non-invasive indices to predict liver fibrosis and their associations with subclinical atheromatous plaque burden and distribution.

Methods

Atheromatous plaque burden (plaque presence, number, and total area) was assessed in the carotid and femoral territories via ultrasonography in 3,981 middle-aged participants without known

SUBMITTER: Leon-Mengibar J 

PROVIDER: S-EPMC12816284 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature