A novel liquid-liquid phase separation related gene signature including ARL6IP4 predicts prognosis and immune landscape in colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) ranks as the second leading cause of cancer-related mortality worldwide. Liquid-liquid phase separation (LLPS) is a phenomenon driven by multivalent weak interactions among biomolecules, such as proteins and nucleic acids, which results in the formation of biomolecular condensates. Abnormal LLPS is closely linked to tumorigenesis and progression. However, a prognostic signature based on LLPS-related genes (LRGs) has rarely been established in CRC.

Methods

We retrieved CRC data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. LRGs were obtained from the DrLLPS database. A novel signature was developed in the TCGA training cohort using univariate Cox regression, least absolute shrinkage and selection operator (

SUBMITTER: Jiang T 

PROVIDER: S-EPMC12816288 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature