Neurogenesis decreases in the offspring of mothers infected with influenza A virus.

ABSTRACT:

Introduction

Seasonal influenza virus infection during pregnancy poses significant risks to maternal and fetal health, contributing to adverse neurodevelopmental outcomes in offspring. This study investigates the impact of maternal infection with two highly pathogenic H1N1 influenza A virus (IAV) strains on hippocampal neurogenesis and glial reactivity in neonatal and juvenile mice.

Methods

Mice were infected with the mouse-adapted influenza virus strain A/WSN/33 (H1N1) or A/California/07/09 (H1N1)pdm09 in a sublethal dose 14 days after pregnancy manifestation. After birth, several pups were sacrificed, brains and hippocampi were isolated and used for RT-qPCR (the expression of IL-1β, iNOS, IFNG, IL-6, TNFa was assessed), immunohistochemistry and Western blot for markers of

SUBMITTER: Rakovskaya A 

PROVIDER: S-EPMC12816302 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature