Lysophosphatidic acid: a promising biomarker for diagnosing sepsis and predicting in-hospital mortality.

ABSTRACT:

Background

Lysophosphatidic acid (LPA) has anti-inflammatory and protective effects in sepsis, yet clinical evidence on its correlation with sepsis progression and outcomes is limited. This study aimed to evaluate the association of plasma LPA levels with sepsis development, severity, and mortality.

Methods

A total of 42 sepsis patients and 29 controls with common infections were included. Among the sepsis patients, 15 succumbed during hospitalization. Plasma LPA levels were measured, and clinical data were retrospectively analyzed.

Results

Plasma LPA was significantly lower in sepsis patients compared to controls, and further reduced in non-survivors. Notably, correlation analyses suggested that LPA levels were negatively correlated with neutrophil count, procalciton

SUBMITTER: Li X 

PROVIDER: S-EPMC12816347 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature