Follicle-stimulating hormone linked to cognitive decline and amyloid burden in postmenopausal women.

ABSTRACT:

Introduction

Women have a higher risk of developing Alzheimer's disease (AD) than men, with hormonal changes during menopause being a potential factor. However, the exact relationship between these hormonal changes, cognitive function, and AD pathology is not fully understood. This study investigates the differential associations between serum follicle-stimulating hormone (FSH) and estradiol levels with cognitive function and cerebral amyloid-βeta (Aβ) deposition, quantified using amyloid positron emission tomography, in postmenopausal women across the spectrum from cognitively normal aging to AD dementia.

Methods

A total of 884 postmenopausal women, aged 60 years or older, were enrolled in the study. Participants were classified into three groups based on their cognitive fu

SUBMITTER: Wang SM 

PROVIDER: S-EPMC12816383 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature