Prior culture-guided prediction of antibiotic susceptibility in recurrent respiratory tract infections: a retrospective cohort analysis.

ABSTRACT:

Background

Recurrent respiratory tract infections (RRTIs) are a serious problem in older adults, necessitating appropriate early empiric antibiotic therapy. However, rising antimicrobial resistance complicates empiric treatment selection. Although prior culture results can offer guidance for empiric decisions, little data exist to quantify their predictive value in RRTIs. Therefore, we constructed a respiratory antibiogram and assessed Bayesian metrics of prior gram-negative isolates for predicting subsequent resistance or susceptibility in this population.

Method

A retrospective cohort included hospitalized RRTI patients (defined as RTIs occurring ≥2 times in 6 months or ≥3 times in 12 months). Patient-specific antibiograms were constructed. A Bayesian prevalence-calibrated

SUBMITTER: Li S 

PROVIDER: S-EPMC12816384 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature