Longitudinal Analysis of Manually and Automatically Classified Circulating Tumor Biomarkers and their Prediction of Survival in Metastatic Colorectal Cancer.

ABSTRACT: Circulating tumor cells (CTCs) and tumor-derived extracellular vesicles (tdEVs) are promising biomarkers for predicting survival and informing treatment decisions in metastatic colorectal cancer (mCRC); yet their clinical application remains limited. In this study, we analyzed CellSearch image archives from 446 patients with mCRC treated in the CAIRO2 study to evaluate the predictive value of CTCs and tdEVs and explore their utility in guiding personalized therapy. Using pharmacodynamic modeling, we examined longitudinal changes in manually and automatically classified CTC and tdEV counts, assessing their relationship with tumor size dynamics and overall survival. Automated tdEV counts demonstrated the strongest association with survival, followed by automated CTCs, which outperformed manu

SUBMITTER: Centanni M 

PROVIDER: S-EPMC12816431 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature