Possible Involvement of Skin-Resident Memory T Cells in Refractory Chronic Alopecia Areata.

ABSTRACT: Alopecia areata is a typical skin disease with unmet needs. So far, it has been understood that the main cause of the intractability of chronic cases is the decrease in inflammatory cell infiltration and falling into the telogen-like phase. However, in some cases, even in long-term chronic cases, inflammatory cell infiltration can be seen, so that we speculate that the long-term persistence of these perifollicular cells may be the reason for the lack of improvement as skin resident memory T (T_RM) cells. To investigate the presence of T_RM, nine treatment-resistant chronic AA patients and 5 acute AA patients were employed for staining with CD69 and CD103 as markers for identifying skin T_RM cells. This study revealed the number of CD8⁺CD103⁺

SUBMITTER: Kageyama R 

PROVIDER: S-EPMC12816445 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature