Targeting NADPH oxidase 2 suppresses the growth of esophageal squamous cell carcinoma by regulating BTG2 pathway.

ABSTRACT:

Background

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2) plays a carcinogenic role in various tumors. Recent study has reported that the carcinogenic mechanism of NOX2 in esophageal squamous cell carcinoma (ESCC) may be associated with the regulation of B-cell translocation gene 2 (BTG2). This study aims to clarify the role of NOX2 in the progression of ESCC.

Materials and methods

NOX2 was knocked down in ESCC cell lines via siRNA transfection to assess its impact on cell function and BTG2 regulation. Tumor tissues from 66 ESCC patients were analyzed for NOX2 and BTG2 expression using immunohistochemistry to determine their clinical significance.

Results

NOX2 deficiency inhibited ESCC cell proliferation, promoted apoptosis, and caused G1 phase a

SUBMITTER: Liu XJ 

PROVIDER: S-EPMC12816450 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature