Comparison of postprocessing metrics in multimetabolic APT-weighted CEST and 2-deoxy-D-glucose-CEST-MRI for differentiating breast cancer subtypes in a murine model.

ABSTRACT:

Background

Chemical exchange saturation transfer (CEST)-magnetic resonance imaging (MRI), particularly amide proton transfer-weighted (APTw)-CEST and 2-deoxy-D-glucose-CEST, holds promise for noninvasive molecular breast cancer (BC) characterization. However, quantification remains challenging due to field inhomogeneities, overlapping exchange pools, and the limited robustness of conventional metrics such as the magnetization transfer ratio asymmetry (MTR_asym). This study evaluates four CEST postprocessing metrics-MTR_asym, Lorentzian amplitudes, MTR relaxation exchange (MTR_REX), and apparent exchange-dependent relaxation (AREX)-for their diagnostic performance in differentiating BC subtypes using endogenous APTw-CEST and exogenous 2-deoxy-D-glucose-

SUBMITTER: Prinz D 

PROVIDER: S-EPMC12816453 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature