Integrative analysis reveals NFIL3 as a prognostic marker in glioblastoma associated with anesthesia and circadian rhythm genes.

ABSTRACT:

Background

Glioblastoma (GBM) is the most aggressive and common form of malignant brain tumor in adults, characterized by poor prognosis and limited treatment options. The molecular mechanisms underlying GBM pathogenesis and progression remain incompletely understood. Recent studies have suggested potential links between anesthesia-related genes and cancer progression, as well as the influence of circadian rhythm disruptions on tumor biology.

Methods

In this study, we conducted a comprehensive analysis using public databases to identify genes that are both related to anesthesia and circadian rhythms, and their association with GBM. We performed an analysis to identify differentially expressed genes (DEGs) in GBM compared to normal brain tissues. NFIL3, a gene implicated in b

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC12816460 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature