Effectiveness and Safety of Aspirin Versus Other Antithrombotics for VTE After Total Hip and Knee Arthroplasty in Real-World Setting.

ABSTRACT: BackgroundVenous thromboembolism (VTE) is a potentially life-threatening complication in patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA). Multiple antithrombotic agents are routinely used to prevent VTE after THA and TKA. However, it remains unclear which anticoagulant is optimal in real-world clinical practice. This study aimed to assess the effectiveness and safety of aspirin and other antithrombotic agents for VTE prophylaxis following THA and TKA.MethodsSeveral electronic databases, including PubMed, Embase, and the Cochrane Library, were systematically searched from inception to January 13th, 2025. The search identified real-world studies assessing the efficacy or safety of aspirin versus other anticoagulants for VTE prophylaxis after THA or TKA. The

SUBMITTER: Zhu YF 

PROVIDER: S-EPMC12816517 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature