A clinical-molecular nomogram for predicting early recurrence following resection of initially unresectable colorectal liver metastases.

ABSTRACT:

Background

Postoperative early recurrence (PER) remains a major challenge to long-term survival after successful conversion therapy and curative resection for initially unresectable colorectal liver metastases (CRLM). Existing prediction models rely heavily on clinicopathological parameters and lack molecular biomarkers, limiting their predictive accuracy.

Objectives

To define the optimal recurrence-free survival (RFS) cutoff for PER and develop a comprehensive predictive nomogram incorporating molecular and clinical variables to predict PER in patients with initially unresectable CRLM who undergo curative resection following conversion therapy.

Design

Retrospective cohort study.

Methods

Clinicopathological and molecular data from 411 patients with initially un

SUBMITTER: Lu YT 

PROVIDER: S-EPMC12816525 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature