Integrated proteomics and metabolomics analysis revealed that macrophage-related signals may be potential biomarkers for oral squamous cell carcinoma.

ABSTRACT: Oral squamous cell carcinoma (OSCC) is a prevalent and aggressive malignancy with poor prognosis, yet the protein-level and metabolic alterations driving disease progression remain poorly characterized. Here, we integrated multi-omics analysis combining proteomics, metabolomics, spatial transcriptomics, and single-cell RNA sequencing data to systematically compare OSCC tumors with matched adjacent non-tumor tissues. Our proteomic profiling identified significant upregulation of immune-related proteins ARPC4 in OSCC, which correlated with poor patient survival. Notably, C1QC-positive macrophages (Macro_C1QC) were identified as the primary source of these dysregulated proteins, with high Macro_C1QC infiltration serving as an independent prognostic marker. Integrated proteo-metabolomic analys

SUBMITTER: Yang B 

PROVIDER: S-EPMC12816574 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature