Iridium complex-loaded biomimetic vesicles enable enhanced photodynamic therapy and immune modulation.

ABSTRACT: The strategic integration of micro/nano-engineering with controlled optical responses is pivotal for advancing solid tumor therapy. We have constructed a biomimetic nanosystem via the precise encapsulation of a flexible-chain iridium complex (IrC8) within giant plasma membrane vesicles (GPMVs) derived from tumor cells. This micro/nano-scale design leverages the endogenous structure of GPMVs to achieve superior biocompatibility and enhance homologous targeting, resulting in a 4.7% increase in cellular uptake compared to the free complex. The encapsulated IrC8 complex serves as a highly efficient photosensitizer, exhibiting a strong optical response characterized by an aggregation-induced emission enhancement factor (I/I₀) > 10 and a high singlet-oxygen quantum yield (ΦΔ = 0.18). Upon photoa

SUBMITTER: Xiaohui Z 

PROVIDER: S-EPMC12816584 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature