Moderating effect of the domains of the cognitive reserve index questionnaire (CRIq) on longitudinal change slopes in episodic memory across the cognitive aging continuum.

ABSTRACT: Cognitive reserve (CR) hypothesis predicts reduced impact of aging and neurodegeneration on cognition in adults who have lived in cognitively stimulating environments. Our study tested the moderating role of socio-behavioral CR proxies on longitudinal episodic memory (EM) decline, one of the cognitive domains that has been suggested to be most sensitive to early deterioration in presymptomatic stages of dementia. 323 participants (≥ 50 years old) from CompAS study were classified into four groups based on baseline diagnosis and progression at 18-24 (T1) and 48-70 months (T2): Subjective cognitive complaints (SCC) who remain stable (SCC-stable), Mild cognitive impairment (MCI) who remain stable (MCI-stable), SCC who progressed to MCI (Prog-to-MCI), and SCC or MCI who progressed to dementia

SUBMITTER: Arora S 

PROVIDER: S-EPMC12816592 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature