Chemical synthesis, bioinformatics and antiproliferative studies of novel pyrimidin-4-yl-1H-pyrazole derivatives in chronic myeloid cancer cells.

ABSTRACT: A series of novel methyl-1-(2-((3,5-dimethylphenyl)amino)pyrimidin-4-yl)-1H-pyrazole derivatives were synthesized, characterized through ¹H and ¹³C NMR and mass spectroscopic techniques and evaluated for their in silico and in vitro antiproliferative activity against leukemia cancer cells sensitive (K562) or resistant to imatinib (K562-IM). Among the studied compounds, only compound 5, with a methyl alcohol at the 4-position of pyrazole ring, and compound 6, with a methyl carboxamide at the 4-position of pyrazole ring, induced a cytotoxic response in both the CML cell lines. Despite its higher cytotoxicity in both cell line, compound 6 was also highly cytotoxic in primary normal human fibroblasts. In contrary, the high cytotoxicity of compound 5 towards both IM sensit

SUBMITTER: Rajasheker KV 

PROVIDER: S-EPMC12816615 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature