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Endoscopic swab sampling as a novel method for gastric Microbiome profiling: A pilot study compared with tissue biopsy.


ABSTRACT:

SUBMITTER: Park G 

PROVIDER: S-EPMC12816699 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature

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Endoscopic swab sampling as a novel method for gastric Microbiome profiling: A pilot study compared with tissue biopsy.

Park Gihong G   Chung Hyunsoo H  

Scientific reports 20251211 1


The gastric microbiome is increasingly recognized in gastric carcinogenesis, extending beyond Helicobacter pylori to oral-associated bacteria. Tissue biopsy is the current standard but is limited in spatial coverage. This pilot study evaluated an endoscopic swab-based approach as an alternative. Paired swab and biopsy samples were obtained from the gastric antrum and body of 16 patients undergoing esophagogastroduodenoscopy (32 swabs, 32 biopsies). Microbiome profiling was performed using 16 S r  ...[more]

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