Trajectory of serum osmolality changes and 28-day mortality risk in patients with sepsis-associated delirium based on the MIMIC-IV database.

ABSTRACT: Serum osmolality (SOSM) levels have been reported to be associated with the prognosis of critically ill patients. The purpose of this study was to analyze the impact of the trajectory of changes in SOSM on the 28-day mortality risk in patients with sepsis-associated delirium (SAD). Latent class trajectory modeling (LCTM) was employed in this retrospective cohort study of patients with SAD from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. SOSM trajectories were derived using LCTM based on three measurements obtained at two-day intervals during the first six days following ICU admission. The relationship between the SOSM and 28-day mortality risk was explored using restricted cubic spline (RCS), Cox regression models, and Kaplan-Meier curves. Subgroup analyses were

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC12816723 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature