Pulmonary Obstruction and Age, Not Activity, Associate With Muscle Oxidative Impairment in Smokers With and Without COPD.

ABSTRACT:

Background

Low muscle oxidative capacity is an extrapulmonary manifestation of chronic obstructive pulmonary disease (COPD) with unclear aetiology. We sought to characterize locomotor muscle oxidative capacity in never smokers and ever smokers with and without COPD and determine clinical and behavioural features associated with low muscle oxidative capacity.

Methods

Two hundred forty-three adults enrolled in the Muscle Health Study, an observational study ancillary to COPDGene. Gastrocnemius oxidative capacity was measured by near-infrared spectroscopy from the muscle oxygen consumption recovery rate constant (k). Physical activity was measured by accelerometry (vector magnitude units [VMU]/min). Pulmonary assessments included spirometry (FEV₁%predicted), diffusin

SUBMITTER: Adami A 

PROVIDER: S-EPMC12816763 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature