White matter structure-function decoupling in juvenile myoclonic epilepsy.

ABSTRACT:

Objective

Accumulating evidence highlights both structural and functional brain alterations in juvenile myoclonic epilepsy (JME), yet how these structural changes within white matter pathways drive functional disorganization remains largely unknown. Here, we aim to investigate white matter structure-function coupling (SFC) in treatment-naïve, newly diagnosed JME.

Methods

Forty-seven patients with JME and 40 demographically matched healthy controls underwent diffusion-weighted imaging (DWI) and resting-state functional magnetic resonance imaging (fMRI). Tract-wise SFC was assessed using a multivariate linear regression, with the amplitude of low-frequency fluctuations as the dependent variable and four microstructural metrics-fractional anisotropy (FA), mean diffusivity (MD),

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12816833 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature