The right kind of rarefaction: Coronary microvascular remodeling in right ventricle failure.

ABSTRACT:

Background

Right ventricular failure (RVF) is the primary determinant of outcomes in pulmonary hypertension (PH). Coronary microvascular dysfunction (CMD), defined by capillary rarefaction and endothelial dysfunction, may contribute to RVF but remains poorly characterized. CMD, defined by capillary rarefaction and endothelial dysfunction, may contribute to RVF through impaired myocardial oxygen delivery and fibrotic remodeling.

Objectives

To characterize right ventricle (RV) CMD and myocardial fibrosis in explanted human hearts and examine associations with echocardiographic and hemodynamic indices of RVF across PH subtypes.

Methods

We retrospectively analyzed 57 adult patients who underwent orthotopic heart transplantation at 3 institutions (2023-2024). Explanted hea

SUBMITTER: Vahdatpour C 

PROVIDER: S-EPMC12816859 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature