Targeted delivery of rhodopsin's assembled core is required for outer segment extension in mouse rod photoreceptors.

ABSTRACT: Vertebrate vision in dim-light environments is initiated by rod photoreceptor cells that express the photopigment rhodopsin, a G protein-coupled receptor. To ensure efficient light capture, rhodopsin is densely packed into hundreds of tightly stacked membrane discs within the rod-shaped outer segment (OS) compartment. Along with its role in eliciting the visual response, rhodopsin serves as a building block necessary for proper OS formation and a trafficking guide for a few OS resident membrane proteins. An interesting aspect of rod homeostasis is that mutations that affect the localization of rhodopsin to the OS result in photoreceptor degeneration. In this study, we focus on determining the properties of rhodopsin's cytosolic C terminus required for either proper OS trafficking or the ca

SUBMITTER: Martinez-Marquez JY 

PROVIDER: S-EPMC12816902 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature